Precautions should be taken when prescribing lorazepam in the elderly, in patients with mild or moderate renal and/or hepatic impairment, in children, in patients with mild or moderate respiratory impairment, in patients with dependence on alcohol or other drugs, and in patients with closed angle glaucoma. The presence of benzodiazepines and glucuronic metabolites in human umbilical cord blood has been detected, this fact indicating the passage of this drug through the placenta.īecause benzodiazepines are secreted in maternal milk, their use is contraindicated in nursing mothers unless the actual benefit to the woman outweighs the potential risk to the child. The use of benzodiazepines seems to be related to a possible increased congenital risk of malformations in the first trimester of pregnancy. If it is prescribed to a woman who could become pregnant during treatment, it will be recommended that when planning a pregnancy or detecting that she is pregnant, contact the doctor to proceed with the withdrawal of treatment. Lorazepam should not be used during pregnancy. Lorazepam is contraindicated in simultaneous treatment with opiates, barbiturates or neuroleptics. Lorazepam is contraindicated in the following cases: Hypersensitivity, myasthenia gravis, sleep apnea syndrome, severe respiratory failure, severe liver failure (risk of encephalopathy). In this way, lorazepam reduces anxiety levels. Lorazepam works by increasing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter located in the brain, by facilitating its binding to the GABAergic receptor. Lorazepam has hypnotic, anticonvulsant, sedative, muscle relaxant, and amnesic activity. Benzodiazepines are only indicated for the treatment of severe disorders that limit the patient's activity or make them to suffer significant stress. It is also prescribed to treat sleep disorders, insomnia, hyperemotivity and neurosis. Lorazepam is prescribed to relieve anxiety as a short-term treatment in periods of anxiety and tension. Lorazepam is an anxiolytic that belongs to the group of benzodiazepines.
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